Fwiw I ran into this problem too when seeding my drive with Google drive sync. What I found was Google drive writes temp files to a hidden directory on the same drive your seeding, then copies them over when complete. This causes constant requests to the same chunks, eventually causing throttling then disconnects.
If your seeding method works the same way you can try my fix. I changed the cache mode from fixed to proportional and left it at 50/50 so the temp chunks could stay in read cache. Before I did this my downloads were constantly at least 50% of my upload speeds even though I don't have verify chunks on nor was I doing any reads against the drive, and eventually disconnects. Prefetch was unusable.
After changing it barely reads during seeding and prefetch works. The only time I get slow downs are when my disk I/o on cache drive can't keep up, but generally only lasts a few seconds but doesn't cause disconnects. Here's my settings:
50tb clouddrive encrypted
80gb proportional cache 50/50
10 dl threads
5 ul threads
Prefetch trigger 5mb
Prefetch fwd 50mb (have tested UpTo 200mb w/o issue but found anything over 50 didn't increase overall avg read speed during burst transfers). Get steady ~15-20MB (150-200mbs) read speed on burst transfer downloads with these settings. Have gig connection but upload throttled to 350 and dl to 250mbs. Unlocking these throttles did not increase download speeds with prefetch set higher. Uploads would surge to 550+ then get throttled by Google regardless of thread count.
Time window 30 seconds
Upload chunk 20mb
Download size 5mb (anything larger caused disconnect/throttling issues and slow performance, and lower would cause the same issues due to clouddrive thread count surge when it tries to catch up)
Chunk cache size 100mb
Provider Google drive
Drive indexing disabled
Antivirus scans disabled on drive
Not sure if drive pool will support, but if your using encryption for each drive you may want to make your drives decrypted, add to drive pool, then use bitlocker to encrypt drive pool drive so your CPU isn't doing multiple encryption/decryption cycles against the same data. I would also disable read striping until your seeding is complete to prevent a download thread surge.