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Sorry, I haven't used CloudDrive nearly enough to be able to tell you whether your plan is actually sound (I use DrivePool and Scanner a lot more) though that may change in the near-ish future. "Drive Usage set to B only having duplicate files." - Have you tested that this works with a pair of local pools? If so, it should also work with a local+cloud pool pairing. "Is read striping needed for users of Pool C to always prioritize Pool A resources first?" - According to the manual the answer is no; regardless of whether Read Striping is checked it will not stripe reads between local and cloud pools, instead it tries to only read from the cloud pool if it can't read from the local pool. However, I have noted forum posts about issues with getting DP to prioritise correctly, and I don't know if those issues have been fixed since those posts as I haven't dug through the CloudDrive changelog recently. https://stablebit.com/Support/DrivePool/2.X/Manual?Section=Performance Options. The rest of your plan seems sound.