Thanks for the reply. You would have to know the context for the server, but I can confidently say that very few files are open at any given time, and I can also rule out malware scanning as a cause.
I played around with this some more last night, after I realized I have another server configured almost identically (save for this one being older) which was not exhibiting this problem. I tried doing the same operations on both servers and noticed that quite a bit more functionality was wrong than just the memory consumption (couldn't restart the DrivePool service, couldn't change some configuration, couldn't reset configuration, etc.). This led me to try and completely nuke the DrivePool installation on the symptomatic machine (even uninstall didn't successfully remove the service). Afterwards I reinstalled it, and as of this morning, it is running at the lowest memory consumption since I updated the version a couple weeks ago. This was 12 hours after the last reboot, where the machine has continuously been exhausting the RAM on the machine in about 24 hours.
I'll continue to monitor, but assuming this trend holds then I would assume that the problem was due to some setting migration or incomplete version upgrade at some point along the way. I had previously tried the repair option earlier this week and that was not effective, but you could determine that almost immediately after reboot.
I'll collect the dump for you if the problem reoccurs over the weekend.
Thanks,
Mike