I have been doing this for a while. With one Drivepool, I have 4 pools and 3 of these are using iSCSI disks on different PC's. Because I have configured each pool to only uses disk on a single PC, it is easy to seperate the pools.
As Drashna says if a complete pool is not available, Drivepool does not know about it, but as soon as one of the iSCSI PC's is powered up, the iSCSI link auto reconnects the disks in a pool, and the pool reappears. I use these iSCSI pools for archiving and backup. Prior to using iSCSI, I used eSATA to add external drives but at that time I did not have seperate pools so I cant confirm if these would behave the same, but I see no reason why not.
The pool contents are then immediately available, and the only impact I have seen is when a pool has been absent for a while it can take some time for Drivepool and Stablebit Scanner to catch up all the admin activities and some of the reporting information can take a time to be updated.
Arthur got a reaction from gringott in Pool that only is powered on occasionally?