What size drive are you using?
Specifically, it looks like Windows (NTFS specifically) may have problems with drives larger than +55TB (the actual limit is 64TB, but there seems to be some window around that.
We would recommend smaller sized disks, or at least smaller volumes on those disks, to ensure you don't exceed this limit. Or ... use ReFS, which doesn't have this limitation.
Specifically, there seems to be a design flaw with the volume snapshot system for drives larger than 64TBs. CHKDSK takes a snapshot of the disk, and then scans *that*. Since ReFS doesn't use chkdsk, this isn't a consideration.
As for preventing corruption, if the integrity checking is enabled (it is by default) when you create a disk, it will always validate the data it gets back from the cloud.
And yes, it is definitely safer to use more, smaller drives, and to pool them together.
As for encryption vs regular, no.
And the data should always be recoverable. Worst case, most data recovery tools will work on the drives.