REALLY liking the odrive.. while its a bit of 'all the eggs in one basket'. its great for offlining stuff you need to have but probably never retrieved again. it defiantly has a file size limit, it seems to have problems with amazon cloud at about 6 gig, so if you use it there you might file split less than 4 or so gig.
its not perfect, and beware updates. they can devalidate your encryption.. and that's a messy 'remove / reattach'.. and its really messy if you do the 'out of the odrive' settings.. not update friendly at all. so live in the odrive, in as few encrypted paths as possible.
between 2 amazon accounts ive both backed up and offlined nearly 50 TB. and still going. if you do system images, use something that can break it into 4 gig chunks. easeus or something, if its a windows image, use a file splitter.
I haven't attempted anything with drive pool drive yet. I would love to disable all the local duplication and have odrive simply copy it to amazon, but ive not tried this yet. it can do simple mirroring. and its very fast. its upload can saturate your bandwidth, if the receiver is capable of it. I have a 100 mb pipe, and I've done better than 500 gig a day.